CB-TSS
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Applications Overview

"...development of precision models and their applications to ADME/Tox models are expected to revolutionize the process of drug discovery by providing a capability for multiple-target identification and high-throughput virtual screening of compounds."             Nature Nov. 2002

   

Mass/energy transport underlies most, if not all, of the physiological processes in organisms: protein production, tissue nourishment, organ function, biosystems operations, to organism homeostasis.  A configurable, computer-based workbench environment that facilitates modeling these processes in fine-grained detail has implications in quantitatively explaining a broad range of physiological behavior.

Image map [click on hotspots]

JKA's CB-TSS platform contains five bio-transport dynamics layers and an inventory of finite elements that, when combined like Legos®, accommodates different physical  structures and material properties.  Thus a user can rapidly simulate a bio-transport process by contributing specific anatomical/physiological domain knowledge in a convenient & compact format.

In addition to eliminating the need for each investigator to 'reinvent' equations for conservation of mass, momentum, energy, et al. and the solutions thereto, as it happens biologists are highly focused on certain anatomies, e.g. humans, thereby leveraging another level of sharing, i.e. domain specific materials properties databases and geometries.   

The feasibility of CB-TSS's Finite Element Analysis [FEA] approach to modeling physiological processes, and its compelling economic logic is supported by the success of analogous platforms in other venues

 
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